Antiproliferative compounds and methods of use thereof

• Main Authors: WHITEFIELD Brandon W, CATHERS Brian E, ARTMAN Gerald D. III, KERCHER Timothy S, TAVARES-GRECO Paula A, LOPEZ-GIRONA Antonia, BRAY Gordon L, CARRANCIO Soraya, CORREA Matthew D, HANSEN Joshua, HAVENS Courtney G, ZOU Nanfei, NAGY Mark A, CARMICHAEL James, LU Xiaoling, PICCOTTI Joseph R, PIERCE Daniel W, MAN Hon-Wah, NARLA Rama K, WONG Lilly L, ALEXANDER Matthew D
• Format: Patent
• Language: English; Hebrew
• Published: 01.03.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myel...