Antiproliferative compounds and methods of use thereof

Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myel...

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Main Authors WHITEFIELD Brandon W, CATHERS Brian E, ARTMAN Gerald D. III, KERCHER Timothy S, TAVARES-GRECO Paula A, LOPEZ-GIRONA Antonia, BRAY Gordon L, CARRANCIO Soraya, CORREA Matthew D, HANSEN Joshua, HAVENS Courtney G, ZOU Nanfei, NAGY Mark A, CARMICHAEL James, LU Xiaoling, PICCOTTI Joseph R, PIERCE Daniel W, MAN Hon-Wah, NARLA Rama K, WONG Lilly L, ALEXANDER Matthew D
Format Patent
LanguageEnglish
Hebrew
Published 01.03.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
AbstractList Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
Author LOPEZ-GIRONA Antonia
KERCHER Timothy S
BRAY Gordon L
WONG Lilly L
ALEXANDER Matthew D
LU Xiaoling
CORREA Matthew D
NARLA Rama K
MAN Hon-Wah
CARMICHAEL James
ZOU Nanfei
WHITEFIELD Brandon W
CATHERS Brian E
CARRANCIO Soraya
ARTMAN Gerald D. III
TAVARES-GRECO Paula A
NAGY Mark A
PICCOTTI Joseph R
PIERCE Daniel W
HAVENS Courtney G
HANSEN Joshua
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– fullname: LOPEZ-GIRONA Antonia
– fullname: BRAY Gordon L
– fullname: CARRANCIO Soraya
– fullname: CORREA Matthew D
– fullname: HANSEN Joshua
– fullname: HAVENS Courtney G
– fullname: ZOU Nanfei
– fullname: NAGY Mark A
– fullname: CARMICHAEL James
– fullname: LU Xiaoling
– fullname: PICCOTTI Joseph R
– fullname: PIERCE Daniel W
– fullname: MAN Hon-Wah
– fullname: NARLA Rama K
– fullname: WONG Lilly L
– fullname: ALEXANDER Matthew D
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KERCHER Timothy S
BRAY Gordon L
WONG Lilly L
CELGENE CORPORATION
ALEXANDER Matthew D
LU Xiaoling
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NARLA Rama K
MAN Hon-Wah
CARMICHAEL James
ZOU Nanfei
WHITEFIELD Brandon W
CATHERS Brian E
CARRANCIO Soraya
ARTMAN Gerald D. III
TAVARES-GRECO Paula A
NAGY Mark A
PICCOTTI Joseph R
PIERCE Daniel W
HAVENS Courtney G
HANSEN Joshua
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– name: TAVARES-GRECO Paula A
– name: WONG Lilly L
– name: CATHERS Brian E
– name: CARRANCIO Soraya
– name: KERCHER Timothy S
– name: WHITEFIELD Brandon W
– name: CORREA Matthew D
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– name: ZOU Nanfei
– name: LOPEZ-GIRONA Antonia
– name: ARTMAN Gerald D. III
– name: MAN Hon-Wah
– name: HAVENS Courtney G
– name: CARMICHAEL James
– name: CELGENE CORPORATION
– name: ALEXANDER Matthew D
– name: HANSEN Joshua
– name: LU Xiaoling
– name: BRAY Gordon L
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Snippet Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a...
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HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Antiproliferative compounds and methods of use thereof
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