Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters

• Main Author: JOSSIAN OPPENHEIMER
• Format: Patent
• Language: English; Hebrew
• Published: 31.12.2017

Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted b...