NOVEL INDANONE AND INDANOLE DERIVATIVES AGAINST TUMOUR AND LEUKEMIA, PROCESS FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

PCT No. PCT/FR95/00814 Sec. 371 Date Dec. 19, 1996 Sec. 102(e) Date Dec. 19, 1996 PCT Filed Jun. 20, 1995 PCT Pub. No. WO96/00205 PCT Pub. Date Jan. 4, 1996(3-hydroxy-4-methoxybenzyl)-7-methylene-1-vinyl-2,3,3a,4,7,7a-hexahydroinden-4-one of formula (I): (I) and 3-(3-hydroxy-4-methoxybenzyl)-4-hydro...

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Main Authors PROVOST,JEAN, LEBOUL,JEAN
Format Patent
LanguageEnglish
Published 28.08.1997
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract PCT No. PCT/FR95/00814 Sec. 371 Date Dec. 19, 1996 Sec. 102(e) Date Dec. 19, 1996 PCT Filed Jun. 20, 1995 PCT Pub. No. WO96/00205 PCT Pub. Date Jan. 4, 1996(3-hydroxy-4-methoxybenzyl)-7-methylene-1-vinyl-2,3,3a,4,7,7a-hexahydroinden-4-one of formula (I): (I) and 3-(3-hydroxy-4-methoxybenzyl)-4-hydroxy-7-methyl-1-vinylindan of formula (II): (II) as well as their stereoisomeric forms are disclosed. Also disclosed are a process for producing these compounds from the plant Ottelia alismoides and pharmaceutical compositions containing them. The novel compounds of formulas (I) and (II) have remarkable antitumor and antileukaemic properties.
AbstractList PCT No. PCT/FR95/00814 Sec. 371 Date Dec. 19, 1996 Sec. 102(e) Date Dec. 19, 1996 PCT Filed Jun. 20, 1995 PCT Pub. No. WO96/00205 PCT Pub. Date Jan. 4, 1996(3-hydroxy-4-methoxybenzyl)-7-methylene-1-vinyl-2,3,3a,4,7,7a-hexahydroinden-4-one of formula (I): (I) and 3-(3-hydroxy-4-methoxybenzyl)-4-hydroxy-7-methyl-1-vinylindan of formula (II): (II) as well as their stereoisomeric forms are disclosed. Also disclosed are a process for producing these compounds from the plant Ottelia alismoides and pharmaceutical compositions containing them. The novel compounds of formulas (I) and (II) have remarkable antitumor and antileukaemic properties.
Author LEBOUL,JEAN
PROVOST,JEAN
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Snippet PCT No. PCT/FR95/00814 Sec. 371 Date Dec. 19, 1996 Sec. 102(e) Date Dec. 19, 1996 PCT Filed Jun. 20, 1995 PCT Pub. No. WO96/00205 PCT Pub. Date Jan. 4,...
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title NOVEL INDANONE AND INDANOLE DERIVATIVES AGAINST TUMOUR AND LEUKEMIA, PROCESS FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
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