2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL-PIPERAZINE DERIVATIVES HAVING 5-HT1A-ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
The present invention is concerned with compounds having 5-HT1A antagonistic activity useful in treating CNS disorders and having formula 2 wherein R1 is halogen, lower alkyl or alkoxy, hydroxy, trifluotomethyl or cyano, m has the value 1 or 2 and n has the value 0 or 1, A represents an alkylene cha...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English |
| Published |
28.04.1997
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| Edition | 6 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention is concerned with compounds having 5-HT1A antagonistic activity useful in treating CNS disorders and having formula 2 wherein R1 is halogen, lower alkyl or alkoxy, hydroxy, trifluotomethyl or cyano, m has the value 1 or 2 and n has the value 0 or 1, A represents an alkylene chain containing 2-6 C-atoms which may be substituted with one or more lower alkyl groups or a monocyclic (hetero)aryl group, and B is methylene, ethylene, carbonyl, sulfinyl, sulfonyl or sulfur, and salts thereof. |
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| AbstractList | The present invention is concerned with compounds having 5-HT1A antagonistic activity useful in treating CNS disorders and having formula 2 wherein R1 is halogen, lower alkyl or alkoxy, hydroxy, trifluotomethyl or cyano, m has the value 1 or 2 and n has the value 0 or 1, A represents an alkylene chain containing 2-6 C-atoms which may be substituted with one or more lower alkyl groups or a monocyclic (hetero)aryl group, and B is methylene, ethylene, carbonyl, sulfinyl, sulfonyl or sulfur, and salts thereof. |
| Author | VAN STEEN,BARTHOLOMEUS JOHANNES SCHIPPER,JACQUES MOS,JOHANNES HARTOG,JAN |
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| Notes | Application Number: HU19940001965 |
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| Snippet | The present invention is concerned with compounds having 5-HT1A antagonistic activity useful in treating CNS disorders and having formula 2 wherein R1 is... |
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| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | 2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL-PIPERAZINE DERIVATIVES HAVING 5-HT1A-ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM |
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