HEPATITIS A VACCINE

• Main Authors: AUNINS,JOHN G, HAGEN,ANNA J, ORELLA,CHARLES J, HENNESSEY,JOHN P, SITRIN,ROBERT D, DEPHILLIPS,PETER A, ABOUD,ROBERT A, BUCKLAND,BARRY C, LEWIS,JOHN A, JUNKER,BETH, OLIVER,CYNTHIA NEWELL
• Format: Patent
• Language: English
• Published: 28.11.1995
• Edition: 5
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

A complete, commercial scale highly reproducible process for producing stable hepatitis A virus (HAV) comprises optimized growth, harvest, and antigen purification conditions, to yield a >95% pure HAV on the basis of protein. Further processing steps yield an inactivated HAV vaccine formulation w...