HEPATITIS A VACCINE
A complete, commercial scale highly reproducible process for producing stable hepatitis A virus (HAV) comprises optimized growth, harvest, and antigen purification conditions, to yield a >95% pure HAV on the basis of protein. Further processing steps yield an inactivated HAV vaccine formulation w...
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| Main Authors | , , , , , , , , , , |
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| Format | Patent |
| Language | English |
| Published |
28.11.1995
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| Edition | 5 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A complete, commercial scale highly reproducible process for producing stable hepatitis A virus (HAV) comprises optimized growth, harvest, and antigen purification conditions, to yield a >95% pure HAV on the basis of protein. Further processing steps yield an inactivated HAV vaccine formulation which is immunogenic, well tolerated, and efficacious in protection against infection by virulent HAV. The product content of protein, carbohydrate, lipid, DNA and RNA is characterized. |
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| AbstractList | A complete, commercial scale highly reproducible process for producing stable hepatitis A virus (HAV) comprises optimized growth, harvest, and antigen purification conditions, to yield a >95% pure HAV on the basis of protein. Further processing steps yield an inactivated HAV vaccine formulation which is immunogenic, well tolerated, and efficacious in protection against infection by virulent HAV. The product content of protein, carbohydrate, lipid, DNA and RNA is characterized. |
| Author | BUCKLAND,BARRY C HENNESSEY,JOHN P AUNINS,JOHN G OLIVER,CYNTHIA NEWELL ORELLA,CHARLES J JUNKER,BETH SITRIN,ROBERT D DEPHILLIPS,PETER A ABOUD,ROBERT A HAGEN,ANNA J LEWIS,JOHN A |
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| Notes | Application Number: HU19950000417 |
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| PublicationDate | 19951128 |
| PublicationDateYYYYMMDD | 1995-11-28 |
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| PublicationYear | 1995 |
| RelatedCompanies | MERCK AND CO. INC |
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| Snippet | A complete, commercial scale highly reproducible process for producing stable hepatitis A virus (HAV) comprises optimized growth, harvest, and antigen... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| Title | HEPATITIS A VACCINE |
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