PROCESS FOR PRODUCING CONDENSED PYRAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

• Main Authors: FERRARI,MARIO,IT, ISETTA,ANNA M.,IT, TRIZIO,DOMENICO,IT, DORIA,GIANFEDERICO,IT
• Format: Patent
• Language: English
• Published: 30.10.1989
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention relates to compounds having the general formula (I) wherein Z represents a C2-C6 alkylene chain or a -CH=CH-CH= group or an -E-CHR4-(CH2)p- group, in which p is zero, 1 or 2; E represents an oxygen atom or a @@S(O)q group, wherein q is zero, 1 or 2; and R4 is hydrogen or C1-C3 alkyl; R1 represents C1-C6 alkyl, benzyl, pyridyl or phenyl, the phenyl being unsubstituted or substituted by one or two substituents chosen independently from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, formylamino and C2-C8 alkanoylamino; each of R2 and R3 is independently: a) hydrogen, halogen or C1-C6 alkyl; b) hydroxy, C1-C6 alkoxy or C3-C4 alkenyloxy; or c) nitro, amino, formylamino or C2-C8 alkanoylamino; and W represents: a') a -CO- @H-S(O)n-CH3 group, wherein n is 1 or 2 and R represents hydrogen or C1-C6 alkyl; or b') a -CO- @H-CN group, wherein Q represents hydrogen, carboxy, CONH2, C2-C7 alkoxycarbonyl or a or a group, wherein Ra represents hydrogen or C1-C20 alkyl and Rb represents C1-C20 alkyl or a -(CH2)m-R5 group, wherein m is zero, 1 or 2 and R5 is: a'') C5-C8 cycloalkyl; b'') pyridyl unsubstituted or substituted by one or two substituents chosen independently from halogen, C1-C6 alkyl and C1-C6 alkoxy; or c'') phenyl unsubstituted or substituted by one or two substituents independently chosen from halogen, CF3, C1-C6 alkyl, C1-C6 alkoxy, amino, nitro, formylamino, C2-C8 alkanoylamino, di(C1-C6 alkyl)amino, hydroxy, formyloxy and C2-C8 alkanoyloxy, and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the treatment of neoplastic diseases and acute and chronic infections of both bacterial and viral origin in mammals.