IMPROVED PROCESS FOR PRODUCING 10-/3-/4-METHYL-PIPERAZIN-1-Y1/-PROPYL/-2TRIFLUOROMETHYL-PHENTHIAZINO AND PHARMACEUTICALLY ACCEPTABLE AND ACID ADDITIONAL SALTS

An improved method is proposed for prepn. of 10-(3-(4-methyl-piperazine-1-il)-propyl)-2-(trifluor-methyl)-phen- tiazine and its acidic salts suitable for medical use. It involves reacting 2-(trifluor-methyl)-phentiazine and 3-(4-methyl-piperazine-1-il)-propyl-halogenid, where halogen atom is chlorin...

Full description

Saved in:
Bibliographic Details
Main Authors TOEREKI,JOZSEF,HU, JAKFALVI,ELEMER,HU, LADANYI,LASZLO,HU, SIMONYI,ISTVAN,HU, DIETZ,ANDRAS,HU, HALMOS,JOZSEF,HU, BECK,IVAN,HU
Format Patent
LanguageEnglish
Published 28.02.1986
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:An improved method is proposed for prepn. of 10-(3-(4-methyl-piperazine-1-il)-propyl)-2-(trifluor-methyl)-phen- tiazine and its acidic salts suitable for medical use. It involves reacting 2-(trifluor-methyl)-phentiazine and 3-(4-methyl-piperazine-1-il)-propyl-halogenid, where halogen atom is chlorine or bromine, in presence of basic condensing agent, and if required, transforming resultant basic cpd. into an acidic salt or by liberating base chemical from acidic salt. - The reaction is carried out in the presence of 1.8-3.0 mole equiv. of an alkali hydroxide (the quantity to be used refers to the quantity of 2-(trifluoro-methyl)-phentiazine). The alkali hydroxide is to be previously heat treated at 30-150 deg.C, in presence of aromatic hydrocarbon and alkanol mixt.
Bibliography:Application Number: HU19840001526