methylparaben cocrystal form "A" of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-l-yl]-[5-methanesulfonyl-2- ((S) -2,2,2-trifluoro- 1 -methyl-ethoxy) -phenyl] -methanone

The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions....

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Main Authors DEYNET-VUCENOVIC, Annette, GRASSMANN, Olaf, PINARD, Emmanuel, SCHWITTER, Urs, BUBENDORF, Andre, LINDENSTRUTH, Kai, DIODONE, Ralph, ROHRER, Franziska E
Format Patent
LanguageEnglish
Hungarian
Published 29.02.2016
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Abstract The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
AbstractList The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
Author LINDENSTRUTH, Kai
DEYNET-VUCENOVIC, Annette
PINARD, Emmanuel
ROHRER, Franziska E
SCHWITTER, Urs
DIODONE, Ralph
GRASSMANN, Olaf
BUBENDORF, Andre
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– fullname: ROHRER, Franziska E
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DocumentTitleAlternate [4-(3-Fluor-5-trifluormetil-piridin-2-il)-piperazin-1-il]-[5-metánszulfonil-2-((S)-2,2,2-trifluor-1-metil-etoxi)- fenil]-metanon "A" kristályformája és metilparabénes társkristálya
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Snippet The present invention relates to four distinct crystalline forms and to an amorphous form of...
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Title methylparaben cocrystal form "A" of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-l-yl]-[5-methanesulfonyl-2- ((S) -2,2,2-trifluoro- 1 -methyl-ethoxy) -phenyl] -methanone
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