A PROCESS FOR THE PREPARATION OF EPOTHILONE ANALOGS AND INTERMEDIATES

• Main Authors: GUO, ZHENRONG, SWAMINATHAN, SHANKAR, LI, WEN SEN, THORNTON, JOHN E
• Format: Patent
• Language: English
• Published: 28.11.2013
• Subjects: APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opended epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the i...