PROCESS FOR PRODUCING 3-{2-[4-(6-FLUORO-BENZO[D]ISOXAZOL-3-YL)PIPERIDINE-1-IL]-ETHYL}-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDINE-4-ONE AND INTERMEDIATES
A találmány tárgya új eljárás az (I) képletű 3-{2-[4-(6-fluor-benzo[d]izoxazol-3-il)-piperidin-1-il]-etil}-2-metil-- 6,7,8,9-tetrahidro-4H-pirido[1,2-a]pirimidin-4-on előállítására. A találmányszerint olyan módon járnak el, hogy 3-(2-amino-etil)-2-metil-6,7,8,9-tetrahidro-4H-pirido[1,2-a]pirimi- din...
Saved in:
Main Authors | , , , , , |
---|---|
Format | Patent |
Language | English Hungarian |
Published |
28.04.2003
|
Edition | 7 |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | A találmány tárgya új eljárás az (I) képletű 3-{2-[4-(6-fluor-benzo[d]izoxazol-3-il)-piperidin-1-il]-etil}-2-metil-- 6,7,8,9-tetrahidro-4H-pirido[1,2-a]pirimidin-4-on előállítására. A találmányszerint olyan módon járnak el, hogy 3-(2-amino-etil)-2-metil-6,7,8,9-tetrahidro-4H-pirido[1,2-a]pirimi- din-4-on-vegyületet egybenzoizoxazolszármazékkal reagáltatnak. A találmány tárgyát képeziktovábbá az új 3-{2-[4-(6-fluor-benzo[d]izoxazol-3-il)-piperidin-1-il]-etil}-2-metil-- 6,7,8,9-tetrahidro-4H-pirido[1,2-a]pirimidin-4-on ésbenzoizoxazolszármazék intermedierek is. ŕ
Process for obtaining 3-2-[4-(6-fluoro-benzo[d]isoxazol-3- yl)-piperidin-1-yl]-ethyl-2-methyl-6,7,8,9-tetrahydro-4H- pyrido-[1,2-a]pyrimidine-4-one The process comprises reacting 3-(2-aminoethyl)-2-methyl- 6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-4-one of formula II with compounds of general formula III where Y and Z are projecting groups which may be the same or different such as halogen or an alkyl or aryl sulphonyloxy group in the presence of an appropriate solvent and base to provide 3-2-[4-6-fluoro- benzo[d]isoxazol-3-yl)piperidin-I-yl]-ethyl-2-methyl- 6,7,8,9-tetrahydro-4Hpyrido [1,2-a] pyrimidine-4-one of general formula I. The said compound has pharmaceutical applications on account of its antipsychotic properties. Products of formulae II and III which are necessary for the performance of this invention are also claimed. |
---|---|
AbstractList | A találmány tárgya új eljárás az (I) képletű 3-{2-[4-(6-fluor-benzo[d]izoxazol-3-il)-piperidin-1-il]-etil}-2-metil-- 6,7,8,9-tetrahidro-4H-pirido[1,2-a]pirimidin-4-on előállítására. A találmányszerint olyan módon járnak el, hogy 3-(2-amino-etil)-2-metil-6,7,8,9-tetrahidro-4H-pirido[1,2-a]pirimi- din-4-on-vegyületet egybenzoizoxazolszármazékkal reagáltatnak. A találmány tárgyát képeziktovábbá az új 3-{2-[4-(6-fluor-benzo[d]izoxazol-3-il)-piperidin-1-il]-etil}-2-metil-- 6,7,8,9-tetrahidro-4H-pirido[1,2-a]pirimidin-4-on ésbenzoizoxazolszármazék intermedierek is. ŕ
Process for obtaining 3-2-[4-(6-fluoro-benzo[d]isoxazol-3- yl)-piperidin-1-yl]-ethyl-2-methyl-6,7,8,9-tetrahydro-4H- pyrido-[1,2-a]pyrimidine-4-one The process comprises reacting 3-(2-aminoethyl)-2-methyl- 6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-4-one of formula II with compounds of general formula III where Y and Z are projecting groups which may be the same or different such as halogen or an alkyl or aryl sulphonyloxy group in the presence of an appropriate solvent and base to provide 3-2-[4-6-fluoro- benzo[d]isoxazol-3-yl)piperidin-I-yl]-ethyl-2-methyl- 6,7,8,9-tetrahydro-4Hpyrido [1,2-a] pyrimidine-4-one of general formula I. The said compound has pharmaceutical applications on account of its antipsychotic properties. Products of formulae II and III which are necessary for the performance of this invention are also claimed. |
Author | DALMASES BARJOAN, PERE HUGUET CLOTET, JOAN DEL CASTILLO NIETO, JUAN CARLOS MARQUILLAS OLONDRIZ, FRANCISCO BOSCH ROVIRA, ANA CALDERO GES, JOSE MARIA |
Author_xml | – fullname: DEL CASTILLO NIETO, JUAN CARLOS – fullname: BOSCH ROVIRA, ANA – fullname: CALDERO GES, JOSE MARIA – fullname: HUGUET CLOTET, JOAN – fullname: DALMASES BARJOAN, PERE – fullname: MARQUILLAS OLONDRIZ, FRANCISCO |
BookMark | eNqFjL1qwzAUhT20Q_rzDNWYgi9UskmbUbGuK4Gsa2QZ4hgTQlGn4gTSLeRt-qB1m-6dznfgnO8muRr3Y5wlX7WnApuGleTZxKotjHtlGZwE9DnMF1DaljzBCt2GejWYhtZyQxYy6OxjbWr0RhmHwMHYATDozp5BQPVLsEif05d0CQGDl7pTkynXUHfTiXqeCpDDT6kujhzIIZNOMeMC-gqVkQGbu-T6ffdxjPd_eZs8lBgKDfGw38bjYfcWx_i51a0QgvOnFc_-X3wDIzpGuQ |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | Eljárás 3-{2-[4-(6-fluor-benzo[d]izoxazol-3-il)-piperidin-1-il]-etil}-2-metil-6,7,8,9-tetrahidro-4H-pirido[1,2-a]pirimidin-4-on előállítására és az eljárás intermedierjei |
Edition | 7 |
ExternalDocumentID | HU222110B1 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_HU222110B13 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 15:44:31 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English Hungarian |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_HU222110B13 |
Notes | Application Number: HU19950000418 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030428&DB=EPODOC&CC=HU&NR=222110B1 |
ParticipantIDs | epo_espacenet_HU222110B1 |
PublicationCentury | 2000 |
PublicationDate | 20030428 |
PublicationDateYYYYMMDD | 2003-04-28 |
PublicationDate_xml | – month: 04 year: 2003 text: 20030428 day: 28 |
PublicationDecade | 2000 |
PublicationYear | 2003 |
RelatedCompanies | LABORATORIOS VITA S.A |
RelatedCompanies_xml | – name: LABORATORIOS VITA S.A |
Score | 2.576212 |
Snippet | A találmány tárgya új eljárás az (I) képletű 3-{2-[4-(6-fluor-benzo[d]izoxazol-3-il)-piperidin-1-il]-etil}-2-metil--... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | PROCESS FOR PRODUCING 3-{2-[4-(6-FLUORO-BENZO[D]ISOXAZOL-3-YL)PIPERIDINE-1-IL]-ETHYL}-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDINE-4-ONE AND INTERMEDIATES |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030428&DB=EPODOC&locale=&CC=HU&NR=222110B1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1NT8JAEN0QNOpNUYPfPRiiCRNpWUo5EFO6i60p3QZaw0cIoVCiFyCC8WD8N_5QpyuoF27TbTrJzmb69u3OviXkGjmDauiRAZE6LAMtjkswpJMxFPQhIoIe0VheB9TwdDukj-1SO0We12dhpE7ouxRHxIwaYb4v5f96_reIxWRt5eIuesGm2X09qLLcmh0n5NzIsVqV-4IJK2dZVTvMec0qwiACXQ150lYyiU5U9vlTLTmTMv8PKPV9su2jr-nygKTiaYbsWut71zJkp7Ha7kZzlXmLQ_LlN4WFwVKQtSlos9ByvAelCB8a9Cjc6FB3Q9EUUONeV_RY32mJttkVLhSh4976jo-MjTkeRzLnuH3ggd1xP0GDhrRAz5fzRr4CAQ-apt1h6Ina4HfwI9FT8xqY_eSh8eODgvC4YnpMkZK6iUakGfDWEbmq88CyAbs7-I3swA7XcSkek_R0No2zRNGjkRYl5U_quEDHcYTDWRoVRpOJVqETVa-ckOwmL6ebX52RPVkHV6CgGeckvXx9iy8Qz5fRpRyKb9d7mH0 |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdZ1NT8JAEIY3BI14U9TgJz0YogkTaVlKORBTusVW224DreEjhFAo0QsQwXgw_ht_qNMV1Iu32TY7SWczffO0s7OEXCIzyJoaaRDJoyrQ8qQCIzqdQEkdoSKoEY3FcUCup1ohve9UOinytNkLI_qEvonmiJhRY8z3lXhfL34_YjFRW7m8iZ7x0vy2GdRZYUPHCZxrBdaomz5n3CgYRt0KC16rjjKIQtdATtqqIhAKUHpsJHtSFn8FpblHtn30NVvtk1Q8y5KMsTl3LUt23PXvbjTXmbc8IJ9-ixsYLAmpTUKbhYbt3UlleFegT-FKhaYT8haHhun1eJ8N7Dbv6D3uQBm6zrVv-0hszPZMhDnbGYAZWF3nAxRwhQVqsVrUijUIzKClW12GnqgFfhcn8b5cVEAfJAP32wcF7pmS7jFJtNRNekTqgdk-JPmmGRgW4OMOfyI7tMJNXMpHJD2bz-IckdRorERJ-ZM8KdFJHOFyVsal8XSq1OhUVmvHJPefl5P_b-VJxgpcZ-jY3sMp2RU1cSUKinZG0quX1_gctX0VXYhl-QIeh5tn |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=PROCESS+FOR+PRODUCING+3-%7B2-%5B4-%286-FLUORO-BENZO%5BD%5DISOXAZOL-3-YL%29PIPERIDINE-1-IL%5D-ETHYL%7D-2-METHYL-6%2C7%2C8%2C9-TETRAHYDRO-4H-PYRIDO%5B1%2C2-A%5DPYRIMIDINE-4-ONE+AND+INTERMEDIATES&rft.inventor=DEL+CASTILLO+NIETO%2C+JUAN+CARLOS&rft.inventor=BOSCH+ROVIRA%2C+ANA&rft.inventor=CALDERO+GES%2C+JOSE+MARIA&rft.inventor=HUGUET+CLOTET%2C+JOAN&rft.inventor=DALMASES+BARJOAN%2C+PERE&rft.inventor=MARQUILLAS+OLONDRIZ%2C+FRANCISCO&rft.date=2003-04-28&rft.externalDBID=B1&rft.externalDocID=HU222110B1 |