OLIGONUCLEOTIDES CONTAINING 5-ALKYL-, 5-(1-ALKENYL)- OR 5-(1-ALKYNYL)-PYRIMIDINE BASES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION

• Main Authors: SAGI,GYULA, OETVOES,LASZLO, FELLEGVARI,IREN, SZABOLCS,OTTONE, SAGI,JANOS, TUEDOES,FERENCNE, EBINGER,KATALIN, RUFF,EVA, SZEMZOE,ATTILA
• Format: Patent
• Language: English
• Published: 28.02.1997
• Edition: 6
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The invention relates to 12 to 30 nucleotide-unit long oligodeoxynucleotides containing at least one 5-substituted pyrimidine base, either uracil or cytosine, where the 5-substituent is a C3-14 n-alkyl group, a C2-8 (E)-n-1-alkenyl group, an ethynyl or a C4-12 n-1-alkynyl group. The oligodeoxynucleo...