NOVEL ANTI-IL 13 ANTIBODIES AND USES THEREOF

• Main Authors: CHANGNING YAN, MASON LU, MATTHEW MOYLE, SEK CHUNG FUNG, DAN HUANG, SANJAYA SINGH
• Format: Patent
• Language: Croatian; English
• Published: 31.05.2012
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

Antagonističko protutijelo protiv ljudskog IL-13, ili njegov antigenski vežući fragment, koje se specifično veže na ljudski IL13, naznačeno time što navedeno protutijelo kompetitivno inhibira vezanje protutijela kojeg proizvodi hibridom 228B/C-1, kojem je pridružen ATCC depozitni broj PTA-5657, na IL-13.Patent sadrži još 29 patentnih zahtjeva. The present invention relates to ant-IL-13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.