DERIVADO DE PIRIDINA Y PIRAZINA PARA EL TRATAMIENTO DE FIBROSIS QUISTICA (CF)

LA PRESENTE INVENCIONPROPORCIONA DERIVADOS DE PIRIDINA Y PIRAZINA, LOS CUALES RESTABLECEN O MEJORAN LA FUNCION DEL REGULADOR DE CONDUCTANCIA TRANSMEMBRANA DE FIBROSIS QUISTICA ( CFTR) MUTANTE Y/ O DE TIPO SILVESTRE, PARA EL TRATAMIENTO DE FIBROSIS QUISTICA, DIPIELESIA CILIAR PRIMARIA, BRONQUITIS PUL...

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Main Authors CATHERINE HOWSHAM, URS BAETTING, KAMLESH JAGDIS BALA, EMMA BUDD, KATRIN SPIEGEL, LEE EDWARDS, GLYN HUHES, DARREN MARK LEGRAND
Format Patent
LanguageSpanish
Published 07.09.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract LA PRESENTE INVENCIONPROPORCIONA DERIVADOS DE PIRIDINA Y PIRAZINA, LOS CUALES RESTABLECEN O MEJORAN LA FUNCION DEL REGULADOR DE CONDUCTANCIA TRANSMEMBRANA DE FIBROSIS QUISTICA ( CFTR) MUTANTE Y/ O DE TIPO SILVESTRE, PARA EL TRATAMIENTO DE FIBROSIS QUISTICA, DIPIELESIA CILIAR PRIMARIA, BRONQUITIS PULMONAR, XERSTOMIA Y QUERATOCONJUTIVITIS SIRE, O ESTREÑIMIENTO ( SINDROME DE INTESTINO IRRITABLE ( IBS), ENFERMEDAD DE INTESTINO IRRITABLE (IBD), INDUCIDO POR OPIOIDE). TAMBIEN SE ABARCAN COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN TALES DERIVADOS. The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat chronic obstructive pulmonary disease. Pharmaceutical compositions comprising such derivatives are also encompassed.
AbstractList LA PRESENTE INVENCIONPROPORCIONA DERIVADOS DE PIRIDINA Y PIRAZINA, LOS CUALES RESTABLECEN O MEJORAN LA FUNCION DEL REGULADOR DE CONDUCTANCIA TRANSMEMBRANA DE FIBROSIS QUISTICA ( CFTR) MUTANTE Y/ O DE TIPO SILVESTRE, PARA EL TRATAMIENTO DE FIBROSIS QUISTICA, DIPIELESIA CILIAR PRIMARIA, BRONQUITIS PULMONAR, XERSTOMIA Y QUERATOCONJUTIVITIS SIRE, O ESTREÑIMIENTO ( SINDROME DE INTESTINO IRRITABLE ( IBS), ENFERMEDAD DE INTESTINO IRRITABLE (IBD), INDUCIDO POR OPIOIDE). TAMBIEN SE ABARCAN COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN TALES DERIVADOS. The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat chronic obstructive pulmonary disease. Pharmaceutical compositions comprising such derivatives are also encompassed.
Author URS BAETTING
GLYN HUHES
KATRIN SPIEGEL
KAMLESH JAGDIS BALA
CATHERINE HOWSHAM
LEE EDWARDS
EMMA BUDD
DARREN MARK LEGRAND
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– fullname: LEE EDWARDS
– fullname: GLYN HUHES
– fullname: DARREN MARK LEGRAND
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Snippet LA PRESENTE INVENCIONPROPORCIONA DERIVADOS DE PIRIDINA Y PIRAZINA, LOS CUALES RESTABLECEN O MEJORAN LA FUNCION DEL REGULADOR DE CONDUCTANCIA TRANSMEMBRANA DE...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title DERIVADO DE PIRIDINA Y PIRAZINA PARA EL TRATAMIENTO DE FIBROSIS QUISTICA (CF)
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