(2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS

• Main Authors: CONNOLLY, Stephen, MACRITCHIE, Jaqueline, Anne, LÖNN, Hans, Roland, AURELL, Carl-Johan, PONTÉN, John Fritiof, SWALLOW, Steven, WATSON, David, Wyn, VAN DE POËL, Amanda, Jane, KARLSSON, Staffan PO, DOYLE, Kevin, James, JONES, Graham, Peter, PALMER, Nicholas, John
• Format: Patent
• Language: Chinese; English
• Published: 15.09.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including...