PHARMACEUTICAL COMPOSITION WITH IMPROVED BIOAVAILABILITY

• Main Authors: SHAH, NAVNIT HARGOVINDAS, ZHANG, YU-E, SANDHU, HARPREET K, MATCHETT, MICHAEL ALLEN, LOMUSCIO, STEVE, MA, HUA
• Format: Patent
• Language: Chinese; English
• Published: 20.05.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to solid dispersions of poorly water soluble compounds, in particular Compound A as disclosed herein, formed by solvent co-precipitation or spray drying, resulting in improved bioavailability, safety and tolerability of said compounds.