MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE

• Main Authors: ELBASHIR, SAYDA, M, ELLSWORTH, JEFF, LYNN, WHORISKEY, SUSAN, CHAKRABORTY, TIRTHA, WOOD, KRISTY, M, HATALA, PAUL, DE FOUGEROLLES, ANTONIN, JOHN, MATTHIAS, SCHRUM, JASON, P, GUILD, JUSTIN, ROY, ATANU, BANCEL, STEPHANE, EJEBE, KENECHI
• Format: Patent
• Language: Chinese; English
• Published: 29.01.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.