IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS

• Main Authors: KALLAN, NICHOLAS, C, SCHLACHTER, STEPHEN, T, MARMSAETER, FREDRIK, P, GRESCHUK, JULIE, MARIE, ROBINSON, JOHN, E, ALLEN, SHELLEY, RIZZI, JAMES, P, MUNSON, MARK, C, LYSSIKATOS, JOSEPH, P, TOPALOV, GEORGE, T, ZHAO, QIAN
• Format: Patent
• Language: English
• Published: 08.10.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5 R6, R7 and R8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. Particular compounds of this invention have also...