SPIRO[CYCLOALKYLBENZENE-1,1'-(1',2',3',4'-TETRAHYDROISOQUINOLINES)] HAVING NEUROPROTECTIVE PROPERTIES

PCT No. PCT/US91/05887 Sec. 371 Date Mar. 16, 1993 Sec. 102(e) Date Mar. 16, 1993 PCT Filed Aug. 19, 1991 PCT Pub. No. WO92/03420 PCT Pub. Date Mar. 5, 1992.Compounds of formula (I), I in which R1 and R2, which may be the same or different, represent hydrogen, C1-6 alkyl, R3 and R4 independently rep...

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Main Authors NAPIER, JAMES, JOSEPH, MATZ, JAMES, RUSSELL, GRIFFITH, RONALD, CONRAD
Format Patent
LanguageEnglish
Published 30.07.1997
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/US91/05887 Sec. 371 Date Mar. 16, 1993 Sec. 102(e) Date Mar. 16, 1993 PCT Filed Aug. 19, 1991 PCT Pub. No. WO92/03420 PCT Pub. Date Mar. 5, 1992.Compounds of formula (I), I in which R1 and R2, which may be the same or different, represent hydrogen, C1-6 alkyl, R3 and R4 independently represent one or more radicals selected from hydrogen, OH, NH2, NO2, halogen, C1-6 alkyl or C1-6 alkoxy and n is an integer from 1-2 inclusive, and pharmaceutically acceptable derivatives thereof are useful as pharmaceuticals; in particular, they possess N-methyl-(d)-aspartate(NMDA) blocking properties and are useful in the treatment and/or prevention of neurodegenerative conditions.
Bibliography:Application Number: GR19970400849T