HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON BASIS OF VARIABLE DOMAINS VL AND DERIVATIVE VHH

• Main Authors: EKIMOVA, Victoria Mikhailovna (RU), viktoria mikhailis asuli, MOROZOV, Dmitriy Valentinovich (RU), dimitri valentinis dze, GONCHAROVA, Olga Vladimirovna (RU), olga vladimiris asuli, SOFRONOVA, Ekaterina Vladimirovna (RU), ekaterina vladimiris asuli, NEMANKIN, Timofey Aleksandrovich (RU), timofei aleksandris dze, CHERNYH, Yulia Sergeevna (RU, iulia sergis asuli, SOLOVIEV, Valeriy Vladimirovich (RU), valeri vladimiris dze, EVDOKIMOV, Stanislav Rudolfovich (RU);, stanislav rudolfis dze, USTYUGOV, Yakov Yurevich (RU), iakov iuris dze, IVANOV, Roman Alexeevich (RU), roman aleksis dze, CHERNOVSKAYA, Tatyana Veniaminovna (RU), tatiana veniaminis asuli, ULITIN, Andrey Borisovich (RU);, andrei borisis dze, KORZHAVIN, Dmitriy Valerievich (RU), dimitri valeris dze
• Format: Patent
• Language: English
• Published: 10.11.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Humanised monoclonal IgG antibodies con¬necting to human IL-17A and containing heavy chain VHH domain and light chain VL domain combination obtained from an animal of Came¬lidae family. The antibodies described have increased affinity and improved aggregation stability. s