OXADIAZOLE-ALKYL-PURINE DERIVATIVES

• Main Authors: Tandosh, Laslo, Marmarosh, Kalatin, Kovach, Gabor, Grtshenen, Agnesh, Lebrecen, Lorand, Vargai, Zoltan, Kermots, Peter, Minker, Emil, Jene, Martin, Heia, Gergel, Antush, Shandor, Bolehovski, Andrea, Kambor, Lezhe, Horvath, Gabor, Virag, Shandor
• Format: Patent
• Language: English
• Published: 06.02.1997
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I and pharmaceutically acceptable salts thereof wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the Formula -(CH2)n-NR2R3 in which group n is an integer 1-3; R2 and R3 each stand for hydrogen or C1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; or R1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzyl The compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.