Methods and processes for application of drug delivery polymeric coatings

• Main Authors: Xiaoping Chen, Jonathan D. McCanless, Michael Cole, Lisa K. Jennings
• Format: Patent
• Language: English
• Published: 26.10.2016
• Subjects: ADHESIVES; BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL PAINT OR INK REMOVERS; CHEMISTRY; COATING COMPOSITIONS, e.g. PAINTS, VARNISHES ORLACQUERS; COMPOSITIONS BASED THEREON; CORRECTING FLUIDS; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DYES; FILLING PASTES; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; INKS; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC MACROMOLECULAR COMPOUNDS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PAINTS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; POLISHES; PROSTHESES; THEIR PREPARATION OR CHEMICAL WORKING-UP; TREATMENT OR PROTECTION OF EYES OR EARS; USE OF MATERIALS THEREFOR; WOODSTAINS

A method of preparing a coated polymeric surface, the method comprising providing a polymeric surface, exposing the surface to a coating formulation and polymerizing the coating formulation on the polymeric surface to obtain the coated polymeric surface; wherein the coating formulation comprises a thiol monomer, an unsaturated monomer and a therapeutic agent. Preferably the thiol monomer is a polythiol and the unsaturated monomer has more than one unsaturated bond, more preferably the thiol monomer is pentaerythritol tetrakis(3-mercaptopropionate) and the unsaturated monomer is triallyl isocyanurate. The therapeutic agent preferably comprises an antibiotic, more preferably rifampicin, minocycline, minocycline hydrochloride and/or minocycline hyclate. The coating formulation may also comprise a radical scavenger, polymerization initiators and/or solvents. The polymeric surface to be coated is preferably expanded polytetrafluoroethylene, polytetrafluoroethylene, polypropylene or polyester. The polymeric coating of the invention may elute therapeutic agents from the product coating and may provide extended release of the therapeutic agents over time.