PROCESS AND THE PREPARATION OF CYCLOHEXANOL DERIVATIVES

4-Trans-(N-isopropylidene-amino)-cyclohexanol of formula I by hydrolizing 4-cis/trans-acetaminocyclohexanol of formula II, and reacting the thus-obtained 4-cis/trans-aminocyclohexanol of formula III with acetone, e.g. in situ. The above compound I is an important intermediate for the preparation of...

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Main Authors JOZSEF PETRO, ANTAL TUNGLER, ILONA SZTRUHAR, GYOERGYI VERECZKEY, ILDIKO RATZ, PAL BENKO, TIBOR MATHE, DANIEL BOZSING, GYOERGY KOVANYI
Format Patent
LanguageEnglish
Published 21.07.1993
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:4-Trans-(N-isopropylidene-amino)-cyclohexanol of formula I by hydrolizing 4-cis/trans-acetaminocyclohexanol of formula II, and reacting the thus-obtained 4-cis/trans-aminocyclohexanol of formula III with acetone, e.g. in situ. The above compound I is an important intermediate for the preparation of ambroxol, which is a bronchosecretolytic agent.
Bibliography:Application Number: GB19900027816