INDOLES
Indole derivatives of the general formula (I) are disclosed: (I) where R1 is H or an alkyl or alkenyl group, R2 is H, or an alkyl, alkenyl, aryl, aralkyl or cycloalkyl group; R3 is H or an alkyl group; R4 and R5 are independently H or an alkyl or propenyl group or together form an aralkylidene group...
Saved in:
Main Authors | , |
---|---|
Format | Patent |
Language | English |
Published |
13.11.1985
|
Edition | 4 |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Indole derivatives of the general formula (I) are disclosed: (I) where R1 is H or an alkyl or alkenyl group, R2 is H, or an alkyl, alkenyl, aryl, aralkyl or cycloalkyl group; R3 is H or an alkyl group; R4 and R5 are independently H or an alkyl or propenyl group or together form an aralkylidene group; and Alk is an optionally substituted alkylene chain; and their physiologically acceptable salts and solutes. These compounds are potentially useful for the treatment of migraine and may be formulated as pharmaceutical compositions in conventional manner. Various methods for the production of the compounds are disclosed including a Fischer-indole cyclization process. |
---|---|
AbstractList | Indole derivatives of the general formula (I) are disclosed: (I) where R1 is H or an alkyl or alkenyl group, R2 is H, or an alkyl, alkenyl, aryl, aralkyl or cycloalkyl group; R3 is H or an alkyl group; R4 and R5 are independently H or an alkyl or propenyl group or together form an aralkylidene group; and Alk is an optionally substituted alkylene chain; and their physiologically acceptable salts and solutes. These compounds are potentially useful for the treatment of migraine and may be formulated as pharmaceutical compositions in conventional manner. Various methods for the production of the compounds are disclosed including a Fischer-indole cyclization process. |
Author | MICHAEL DENNIS DOWLE IAN HAROLD COATS |
Author_xml | – fullname: MICHAEL DENNIS DOWLE – fullname: IAN HAROLD COATS |
BookMark | eNrjYmDJy89L5WRg9_Rz8fdxDeZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHuTkaGRiZGhgZOxoRVAABGJhvA |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
Edition | 4 |
ExternalDocumentID | GB2124210B |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_GB2124210B3 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 13:07:24 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_GB2124210B3 |
Notes | Application Number: GB19830015564 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19851113&DB=EPODOC&CC=GB&NR=2124210B |
ParticipantIDs | epo_espacenet_GB2124210B |
PublicationCentury | 1900 |
PublicationDate | 19851113 |
PublicationDateYYYYMMDD | 1985-11-13 |
PublicationDate_xml | – month: 11 year: 1985 text: 19851113 day: 13 |
PublicationDecade | 1980 |
PublicationYear | 1985 |
RelatedCompanies | GLAXO GROUP LIMITED |
RelatedCompanies_xml | – name: GLAXO GROUP LIMITED |
Score | 2.3627288 |
Snippet | Indole derivatives of the general formula (I) are disclosed: (I) where R1 is H or an alkyl or alkenyl group, R2 is H, or an alkyl, alkenyl, aryl, aralkyl or... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | INDOLES |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19851113&DB=EPODOC&locale=&CC=GB&NR=2124210B |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQsUg0SgVWC8m6ZqbGZromKSlmuklJyUBuajJo2ivRwsQUtN_Z18_MI9TEK8I0gokhA7YXBnxOaDn4cERgjkoG5vcScHldgBjEcgGvrSzWT8oECuXbu4XYuqilQLaLgZoPhsZqLk62rgH-Lv7Oas7Otu5Oan5BwIwJmvs0cGJmYAU1okGn7LuGOYH2pBQgVyhuggxsAUCz8kqEGJhS84QZOJ1h964JM3D4Qqe7gUxozisWYWD39HPx93ENFmWQd3MNcfbQBZoYD3d8vLsTzGpjMQYWYJc-VYJBIdUUdO14GrD5lZxsYp6YZplknJYImtFMBdbYyYlJkgwSuEyRwi0lzcAFCgLQTjlDYxkGlpKi0lRZYJVZkiQH9i0AcNluKA |
link.rule.ids | 230,309,786,891,25594,76906 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQsUg0SgVWC8m6ZqbGZromKSlmuklJyUBuajJo2ivRwsQUtN_Z18_MI9TEK8I0gokhA7YXBnxOaDn4cERgjkoG5vcScHldgBjEcgGvrSzWT8oECuXbu4XYuqilQLaLgZoPhsZqLk62rgH-Lv7Oas7Otu5Oan5BwIwJmvs0cGJmYDUHnc0LajiFOYH2pBQgVyhuggxsAUCz8kqEGJhS84QZOJ1h964JM3D4Qqe7gUxozisWYWD39HPx93ENFmWQd3MNcfbQBZoYD3d8vLsTzGpjMQYWYJc-VYJBIdUUdO14GrD5lZxsYp6YZplknJYImtFMBdbYyYlJkgwSuEyRwi0lz8DpEeLrE-_j6ectzcAFCg7QrjlDYxkGlpKi0lRZYPVZkiQH9jkAvkdxFQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=INDOLES&rft.inventor=MICHAEL+DENNIS+DOWLE&rft.inventor=IAN+HAROLD+COATS&rft.date=1985-11-13&rft.externalDBID=B&rft.externalDocID=GB2124210B |