COMPOSES NOUVEAUX DE 1,2-ETHYLENEDIAMINE ET COMPOSITION PHARMACEUTIQUE LES CONTENANT

Compounds of the general formula I wherein R represents a halophenyl, dihalophenyl, nitrophenyl, cyanophenyl or trifluoromethylphenyl group; X represents a single bond, -CH2-, -OCH2-, SCH2, -S(O)-CH2-, -S(O)2-CH2- or -CH2CH2- R represents hydrogen or C1-3 alkyl; R represents a phenyl group substitut...

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Bibliographic Details
Main Author BRIAN GEOFFREY MAIN
Format Patent
LanguageFrench
Published 30.09.1994
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of the general formula I wherein R represents a halophenyl, dihalophenyl, nitrophenyl, cyanophenyl or trifluoromethylphenyl group; X represents a single bond, -CH2-, -OCH2-, SCH2, -S(O)-CH2-, -S(O)2-CH2- or -CH2CH2- R represents hydrogen or C1-3 alkyl; R represents a phenyl group substituted in the meta-position by a radical containing an organic base, an organic acid or a quaternary ammonium salt and optionally further substituted. R and R which may be the samme or different each represents a C3-5alkenyl, C3-5alkynyl, C1-6alkyl, or C4-7cycloalkylalkyl group, or together with the intervening nitrogen atom represents a 4-7 membered heterocyclic ring, and the pharmaceutically acceptable salts thereof are useful for the treatment of hypertension and/or inflammation in the warm-blooded animals. Also disclosed are processes for their preparation and pharmaceutical compositions containing them.
Bibliography:Application Number: FR19890000705