Menetelmä terapeuttisesti käyttökelpoisten trisubstituoitujen sykloalkaanijohdannaisten valmistamiseksi

• Main Authors: BAJNOGEL, JUDIT, SZIRT NEE KISZELLY, ENIKO, SIMIG, GYULA, KARAFFA, ERIKA, BLASKO, GABOR, BUDAI, ZOLTAN, MEZEI, TIBOR, REITER NEE ESSES, KLARA, SZEMEREDI, KATALIN, FEKETE, MARTON, EGYED, ANDRAS
• Format: Patent
• Language: Finnish; Swedish
• Published: 11.04.1994
• Edition: 5
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A subject-matter of the invention are (phenylmethylene)-2-(alkyl)-1-[ omega -(amino)-alkoxyimino]-cycloalkane derivatives of general formula wherein R represents hydrogen, C1-4 alkyl or hydroxyl, R1 stands for C1-12 alkyl, R2 and R3 independently each represents hydrogen, a C1-12 alkyl group, optionally substituted by hydroxy, or a C2-12 alkenyl group, or R2 and R3 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocyclic ring, optionally comprising an oxygen, sulfur or a further nitrogen atom, which latter optionally may carry a phenyl, benzyl or C1-4 alkyl substituent, R4 and R5 independently each stands for hydrogen, halogen or a C1-4 alkoxy group, or together represent a 3,4-methylenedioxy group, n is an integer from 2 to 5 and A represents a valency bond or a -CH2-group, as well as stereo and optically active isomers and their mixtures, acid-addition salts and quaternary ammonium derivatives thereof. Furthermore the invention is concerned with a process for preparing these compounds as well as medicaments containing them and the use of them for preparing medicaments, particularly having ulcus and gastric-acid-secretion inhibiting effects.