FOERFARANDE FOER FRAMSTAELLNING AV FARMACEUTISKT VAERDEFULLA AMINOSYRADERIVAT

Compounds of the formula wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms, or phenyl(alkyl of 1 to 6 carbon atoms); R2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms); R3 is hydrogen or alkyl of 1 to 6 carbon atoms; n and m are each independently 0, 1 or 2, the...

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Main Authors HOEFKE,WOLFGANG, ROOS,OTTO, SCHNORRENBERG,GERD, GAIDA,WOLFRAM, WIEDEMANN,INGRID, LOESEL,WALTER
Format Patent
LanguageFinnish
Swedish
Published 10.09.1990
Edition5
Subjects
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Abstract Compounds of the formula wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms, or phenyl(alkyl of 1 to 6 carbon atoms); R2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms); R3 is hydrogen or alkyl of 1 to 6 carbon atoms; n and m are each independently 0, 1 or 2, the sum of n and m being 1 or 2; X, Y and Z are each independently oxygen, sulfur, -NR4-, =CR5-, -CHR5-, provided that only one of X, Y and Z is O, S, and one or two of X, Y and Z are -NR4-; R4 is hydrogen or alkyl of 1 to 4 carbon atoms; and R5 is hydrogen or, together with a vicinal radical R5, a phenyl ring, or when m and n are both 1, the dihydro form with its double bond in conjugation with the C-term=inal carboxylic group; or a non-toxic, pharmacologically acceptable salt thereof. The compounds as well as their salts are useful as antihypertensives.
AbstractList Compounds of the formula wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms, or phenyl(alkyl of 1 to 6 carbon atoms); R2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms); R3 is hydrogen or alkyl of 1 to 6 carbon atoms; n and m are each independently 0, 1 or 2, the sum of n and m being 1 or 2; X, Y and Z are each independently oxygen, sulfur, -NR4-, =CR5-, -CHR5-, provided that only one of X, Y and Z is O, S, and one or two of X, Y and Z are -NR4-; R4 is hydrogen or alkyl of 1 to 4 carbon atoms; and R5 is hydrogen or, together with a vicinal radical R5, a phenyl ring, or when m and n are both 1, the dihydro form with its double bond in conjugation with the C-term=inal carboxylic group; or a non-toxic, pharmacologically acceptable salt thereof. The compounds as well as their salts are useful as antihypertensives.
Author WIEDEMANN,INGRID
SCHNORRENBERG,GERD
ROOS,OTTO
LOESEL,WALTER
GAIDA,WOLFRAM
HOEFKE,WOLFGANG
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– fullname: LOESEL,WALTER
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DocumentTitleAlternate Förfarande för framställning av farmaceutiskt värdefulla aminosyraderi vat
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Snippet Compounds of the formula wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms, or phenyl(alkyl of 1 to 6 carbon atoms); R2 is hydrogen, alkyl of 1 to 4 carbon...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title FOERFARANDE FOER FRAMSTAELLNING AV FARMACEUTISKT VAERDEFULLA AMINOSYRADERIVAT
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