FOERFARANDE FOER FRAMSTAELLNING AV DERIVAT AV KINUKLIDIN
Process for the preparation of compounds of the formula: (I) in which X is H, Cl, Br, I or OH, in which 3-methylene quinuclidine is reacted with an aluminum hydride, in an appropriate solvent and in the presence of a catalytic quantity of a halide of a transition metal, the molar ratio being at leas...
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Main Authors | , , |
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Format | Patent |
Language | Finnish Swedish |
Published |
10.09.1987
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Edition | 4 |
Subjects | |
Online Access | Get full text |
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Abstract | Process for the preparation of compounds of the formula: (I) in which X is H, Cl, Br, I or OH, in which 3-methylene quinuclidine is reacted with an aluminum hydride, in an appropriate solvent and in the presence of a catalytic quantity of a halide of a transition metal, the molar ratio being at least equal to 0.6, the product formed is reacted in situ with an ester, and then the product thus formed is reacted in situ with an electrophilic reactant which is capable of yielding an atom or group X as defined with reference to formula (I). The compounds of formula (I) can be used for the preparation of medicaments. |
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AbstractList | Process for the preparation of compounds of the formula: (I) in which X is H, Cl, Br, I or OH, in which 3-methylene quinuclidine is reacted with an aluminum hydride, in an appropriate solvent and in the presence of a catalytic quantity of a halide of a transition metal, the molar ratio being at least equal to 0.6, the product formed is reacted in situ with an ester, and then the product thus formed is reacted in situ with an electrophilic reactant which is capable of yielding an atom or group X as defined with reference to formula (I). The compounds of formula (I) can be used for the preparation of medicaments. |
Author | LEGROUX,DIDIER HODAC,FRANCOISE BONDIOU,JEAN-CLAUDE |
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Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | Förfarande för framställning av derivat av kinuklidin. |
Edition | 4 |
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Notes | Application Number: FI19830002939 |
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RelatedCompanies | PHARMUKA LABORATOIRES |
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Snippet | Process for the preparation of compounds of the formula: (I) in which X is H, Cl, Br, I or OH, in which 3-methylene quinuclidine is reacted with an aluminum... |
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SubjectTerms | APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING |
Title | FOERFARANDE FOER FRAMSTAELLNING AV DERIVAT AV KINUKLIDIN |
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