Inhibidores de MCL1 macrocíclicos para tratar el cáncer
Un compuesto que es acido 17-cloro-5,13,14,22-tetrametil-28-oxa-2,9-ditia-5,6,12,13,22- pentaazaheptaciclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaeno- 23-carboxilico (formula I) **(Ver fórmula)** o una de sus sales farmaceuticamente a...
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Main Authors | , , , , , , , , , , , |
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Format | Patent |
Language | Spanish |
Published |
03.11.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Un compuesto que es acido 17-cloro-5,13,14,22-tetrametil-28-oxa-2,9-ditia-5,6,12,13,22- pentaazaheptaciclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaeno- 23-carboxilico (formula I) **(Ver fórmula)** o una de sus sales farmaceuticamente aceptables.
Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I)and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions. |
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Bibliography: | Application Number: ES20170720720T |