Derivados de tieno[2,3-c]pirrol-4-ona como inhibidores de ERK

Un compuesto de fórmula:**Fórmula** en la que: R1 es**Fórmula** R2 y R3 son metilo o R2 y R3 pueden tomarse juntas para formar ciclopropilo; R4 es hidrógeno, metilo, cloro, flúor o trifluorometilo; y R5 es**Fórmula** o una sal farmacéuticamente aceptable del mismo. The present invention provides thi...

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Main Authors MCMILLEN, William T, CORTEZ, Guillermo S, JOSEPH, Sajan, MCLEAN, Johnathan Alexander, RODRIGUEZ, Michael John, ZHAO, Gaiying
Format Patent
LanguageSpanish
Published 22.01.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Un compuesto de fórmula:**Fórmula** en la que: R1 es**Fórmula** R2 y R3 son metilo o R2 y R3 pueden tomarse juntas para formar ciclopropilo; R4 es hidrógeno, metilo, cloro, flúor o trifluorometilo; y R5 es**Fórmula** o una sal farmacéuticamente aceptable del mismo. The present invention provides thieno[2,3-c]pyrrol-4-one compounds that inhibit activity of extracellular-signal-regulated kinase (ERK) and may be useful in the treatment of cancer.
AbstractList Un compuesto de fórmula:**Fórmula** en la que: R1 es**Fórmula** R2 y R3 son metilo o R2 y R3 pueden tomarse juntas para formar ciclopropilo; R4 es hidrógeno, metilo, cloro, flúor o trifluorometilo; y R5 es**Fórmula** o una sal farmacéuticamente aceptable del mismo. The present invention provides thieno[2,3-c]pyrrol-4-one compounds that inhibit activity of extracellular-signal-regulated kinase (ERK) and may be useful in the treatment of cancer.
Author JOSEPH, Sajan
ZHAO, Gaiying
RODRIGUEZ, Michael John
MCLEAN, Johnathan Alexander
CORTEZ, Guillermo S
MCMILLEN, William T
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– fullname: RODRIGUEZ, Michael John
– fullname: ZHAO, Gaiying
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Snippet Un compuesto de fórmula:**Fórmula** en la que: R1 es**Fórmula** R2 y R3 son metilo o R2 y R3 pueden tomarse juntas para formar ciclopropilo; R4 es hidrógeno,...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Derivados de tieno[2,3-c]pirrol-4-ona como inhibidores de ERK
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