Vacuna recombinante para la rinitis infecciosa aviar y proceso para producir la misma

• Main Authors: Sakaguchi, Masashi, Mizokami, Hiroshi, Sakamoto, Ryuichi, Baba, Susumu
• Format: Patent
• Language: Spanish
• Published: 13.06.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Una vacuna recombinante de rinitis infecciosa aviar que comprende como principio activo un péptido que consiste en una secuencia que comprende la secuencia de aminoácidos que se muestra en la SEQ ID NO: 35, estando comprendida dicha secuencia en la secuencia de aminoácidos que se muestra en la SEQ ID NO: 1 con la adición de 1 a 200 restos de aminoácidos en su extremo N y/o extremo C. A recombinant avian infectious coryza vaccine and a process for preparing the same are provided. A process for preparing a recombinant avian infectious coryza vaccine which comprises step of constructing E. coli that may produce as an inclusion body a fusion peptide consisting of peptides derived from outer-membrane protein of Avibacterium paragarinarum serotype A and serotype C, step of culturing said E. coli and collecting: and purifying inclusion body from culture, and step of preparing a preparation comprising said purified inclusion body, and an avian infectious coryza vaccine comprising as an active ingredient the fusion peptide. A linker sequence may be inserted between the respective peptides comprising the fusion peptide. For the peptide derived from the serotypes A and C, an amino acid sequence region, of Region 2 or its vicinity responsible for protection from infection may be used.