Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN

• Main Authors: KELNAR, KEVIN, OVCHARENKO, DMITRIY, BROWN, DAVID, CHENG, ANGIE, JARVIS, RICH, DEVROE, ERIC, FORD, LANCE, BYROM, MIKE
• Format: Patent
• Language: Spanish
• Published: 07.10.2014
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Una molécula de ácido nucleico miARN sintético que comprende una secuencia con una identidad de secuencia de al menos el 80% con la secuencia del miR-101 maduro humano para su uso en la terapia de un cáncer. The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that arc relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.