OLIGONUCLEOTIDOS ANTISENTIDO CONTRA VHS 1, ASI COMO SU PREPARACION

• Main Authors: KRETZSCHMAR, GERHARD, HELSBERG, MATTHIAS, WINKLER, IRVIN, UHLMANN, EUGEN, PEYMAN, ANUSCHIRWAN, MAG, MATTHIAS
• Format: Patent
• Language: Spanish
• Published: 16.05.2006
• Edition: 4
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; VINEGAR; WINE

Oligonucleótidos antisentido con las secuencias (Herp099): 5''-G*C*G G G G C T C C A T G G G G G T*C*G-3'' (HerpOl 8): 5''-G*C*A G G A G G A T G C T G A G G A*G*G-3'' (Herp002):5''-G*G*G G C G G G G C T C C A T G G G*G*G-3'' (Herp112):5''-G*G*CGGGGCTCCATGGGGG*T*C-3'' (Herp034): 5''-G*G*G G C T C C A T G G G G G T C G*T*A-3'' (Herp024): 5''-A*A*G A G G T C C A T T G G G T G G*G*G-3'' o (Herp028): 5''-G*G*C C C T G C T G T T C C G T G G*C*G-3'', en donde el símbolo * significa que el enlace fosfodiéster está sustituido por un puente fosfotioato. The invention relates to novel antisense oligonucleotides having the sequences AO1 (Herp099): +TR 5'-GCGGGGCTCCATGGGGGTCG-3' (SEQ ID NO:1) AO2 (Herp018): +TR 5'-GCAGGAGGATGCTGAGGAGG-3' (SEQ ID NO:2) AO3 (Herp002): +TR 5'-GGGGCGGGGCTCCATGGGGG-3' (SEQ ID NO:3) AO4 (Herp112): +TR 5'-GGCGGGGCTCCATGGGGGTC-3' (SEQ ID NO:4) AO5 (Herp034): +TR 5'-GGGGCTCCATGGGGGTCGTA-3' (SEQ ID NO:5) AO6 (Herp024): +TR 5'-AAGAGGTCCATTGGGTGGGG-3' (SEQ ID NO:6) AO7 (Herp028): +TR 5'-GGCCCTGCTGTTCCGTGGCG-3' (SEQ ID NO: 7). and their mixtures, homologs or modified forms, against HSV 1.