INMUNOMODULADOR, INHIBIDOR DE LA ADHERENCIA CELULAR, Y AGENTE QUE PERMITE TRATAR Y PREVENIR ENFERMEDADES AUTOINMUNES

• Main Authors: SHIMOTORI, TOMOYA, AIKAWA, YUKIHIKO, TANAKA, KEIICHI, INABA, TAKIHIRO, MAKINO, SHINJI, OSHIO, ICHIRO
• Format: Patent
• Language: Spanish
• Published: 16.11.2001
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

UN DERIVADO DE 4H-1-BENZOPIRAN-4-ONA DE LA FORMULA GENERAL [1], O UNA SAL DEL MISMO QUE EJERCE UNOS EFECTOS EXCELENTES DE INMUNOMODULACION Y DE INHIBICION DE LA ADHESION CELULAR Y SE ESPERA QUE POSEA TAMBIEN EL EFECTO DE ALIVIAR LAS ENFERMEDADES AUTOINMUNES A UN NIVEL COMPARABLE AL DE LOS ESTEROIDES. POR TANTO, EL COMPUESTO DE LA FORMULA GENERAL [1] ES UTIL PARA EL TRATAMIENTO Y PREVENCION DE ENFERMEDADES AUTOINMUNES CAUSADAS FUNDAMENTALMENTE POR UNA INMUNOPATIA O UNA ADHESION CELULAR ACELERADA DE FORMA ANORMAL, POR EJEMPLO, ARTRITIS REUMATICA CRONICA, ERICEMATOSIS DE LUPUS SISTEMICO, ESCLEREMAS, ENFERMEDADES DEL TEJIDO CONJUNTIVO MIXTO, POLIARTERITIS NUDOSA, LA POLIMIOSITIS/DERMATOMIOSITIS, SINDROME DE SJOGREN, ENFERMEDAD DE BEHCET, ESCLEROSIS MULTIPLE, DIABETES AUTOINMUNE, ENFERMEDAD DE HASHIMOTO, PSORIASIS, MIXEDEMA PRIMARIO, ANEMIA PERNICIOSA, ADINAMIA AGUDA, COLITIS ULCERATIVA, HEPATITIS CRONICA ACTIVA, ANEMIA HEMOLITICA AUTOINMUNE Y PURPURA TROMBOCITOPENICA IDIOPATICA. A 4H-1-benzopyran-4-one derivative of general formula Ä1Ü, or a salt thereof exerts excellent effects of immunomodulation and cell adhesion inhibition, and is further expected to have the effect of relieving autoimmune diseases at a level comparable to that of steroids. Thus the compound of general formula Ä1Ü is useful in the treatment and prevention of autoimmune diseases fundamentally caused by immunopathy or abnormally accelerated cell adhesion, for example, chronic rheumatoid arthritis, systemic lupus erythematosus, sclerema, mixed connective tissue disease, polyarteritis nodosa, polymyositis/dermatomyositis, Sjögren's syndrome, Behcet's disease, multiple sclerosis, autoimmune diabetes, Hashimoto's disease, psoriasis, primary myxedema, pernicious anemia, serious adynamia, ulcerative colitis, chronic active hepatitis, autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura.