SYSTEMS AND METHODS TO IDENTIFY MHC-ASSOCIATED ANTIGENS FOR THERAPEUTIC INTERVENTION
The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHIC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele.
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| Main Authors | , , , , , , , , |
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| Format | Patent |
| Language | English French German |
| Published |
04.09.2024
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| Online Access | Get full text |
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| Abstract | The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHIC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele. |
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| AbstractList | The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHIC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele. |
| Author | CHAN, Pamela Pui Fung LI, Juan HEIDERSBACH, Amy Jeane HALEY, Benjamin Joseph BLANCHETTE, Craig GURUNG, Hem Raj ROSE, Christopher Michael TONG, Ann-Jay DARWISH, Martine Abraham |
| Author_xml | – fullname: LI, Juan – fullname: HALEY, Benjamin Joseph – fullname: GURUNG, Hem Raj – fullname: HEIDERSBACH, Amy Jeane – fullname: ROSE, Christopher Michael – fullname: CHAN, Pamela Pui Fung – fullname: TONG, Ann-Jay – fullname: BLANCHETTE, Craig – fullname: DARWISH, Martine Abraham |
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| DocumentTitleAlternate | SYSTÈMES ET MÉTHODES POUR IDENTIFIER DES ANTIGÈNES ASSOCIÉS AU CMH POUR UNE INTERVENTION THÉRAPEUTIQUE SYSTEME UND VERFAHREN ZUR IDENTIFIZIERUNG MHC-ASSOZIIERTER ANTIGENE FÜR THERAPEUTISCHE INTERVENTIONEN |
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| Notes | Application Number: EP20220826273 |
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| RelatedCompanies | Genentech, Inc |
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| Snippet | The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| Title | SYSTEMS AND METHODS TO IDENTIFY MHC-ASSOCIATED ANTIGENS FOR THERAPEUTIC INTERVENTION |
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