ENHANCED LATERAL FLOW ASSAYS AND DEVICES FOR DETECTING ANALYTES IN BLOOD SAMPLES

• Main Authors: NGUYEN, Trong, BESHAY, Manal, ORTEGA, Maria
• Format: Patent
• Language: English; French; German
• Published: 14.08.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

A lateral flow device for detecting an analyte in a sample, the device comprising: a sample region; a conjugate region comprising: a detection agent that binds an analyte; a hybridization initiator coupled to the detection agent; a plurality of nucleic acid probes, wherein the plurality of nucleic acid probes comprises a first nucleic acid probe and a second nucleic acid probe, and a third nucleic acid probe; wherein the first nucleic acid probe hybridizes to a portion of the hybridization initiator and a portion of the second nucleic acid probe; wherein the second nucleic acid probe hybridizes to a portion of the first nucleic acid probe and a portion of the third nucleic acid probe; and wherein the third nucleic acid probe hybridizes to a portion of the second nucleic acid probe; and a detection region comprising: a capture agent immobilized on the detection region.