FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN

The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic ki...

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Main Authors LIPOVSEK, Dasa, ZHAO, Wenjun, KRYSTEK, Stanley, Richard, Jr, MADIREDDI, Malavi, WEI, Hui, KOZHICH, Alexander, T, ENGLE, Linda, RAKESTRAW, Ginger, Chao, CORBETT, Martin, J, RAMAMURTHY, Vidhyashankar, CLOAD, Sharon, YAMNIUK, Aaron, P, SWAIN, Joanna F
Format Patent
LanguageEnglish
French
German
Published 10.07.2024
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Abstract The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.
AbstractList The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.
Author RAKESTRAW, Ginger, Chao
YAMNIUK, Aaron, P
KOZHICH, Alexander, T
WEI, Hui
ZHAO, Wenjun
CLOAD, Sharon
CORBETT, Martin, J
KRYSTEK, Stanley, Richard, Jr
RAMAMURTHY, Vidhyashankar
LIPOVSEK, Dasa
SWAIN, Joanna F
ENGLE, Linda
MADIREDDI, Malavi
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– fullname: KOZHICH, Alexander, T
– fullname: ENGLE, Linda
– fullname: RAKESTRAW, Ginger, Chao
– fullname: CORBETT, Martin, J
– fullname: RAMAMURTHY, Vidhyashankar
– fullname: CLOAD, Sharon
– fullname: YAMNIUK, Aaron, P
– fullname: SWAIN, Joanna F
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DocumentTitleAlternate ÉCHAFAUDAGES DES DOMAINES DE LA PROTÉINE DE FIBRONECTINE SE LIANT À LA MYOSTATINE
FIBRONECTINBASIERTE GERÜSTDOMÄNENPROTEINE ZUR BINDUNG AN MYOSTATIN
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Snippet The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in...
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SubjectTerms CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Title FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN
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