COMPOUNDS FOR THE MANAGEMENT OF CELL STEMNESS AND INVASION IN CANCER AND RELATED DISEASES

The present invention relates to compound of general formula (I):wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in cancer such as Glioblastoma. The compounds have shown to be useful in therapy as modulators of TAP7...

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Bibliographic Details
Main Authors MARÍN VIEIRA, Maria del Carmen, MARTÍN LÓPEZ, Marta, VINUESA NAVARRO, María de los Angeles, CAÑEDO HERNÁNDEZ, María Librada, FERNÁNDEZ MEDARDE, Antonio, MARQUÉS MARTÍNEZ, Margarita M, VILLOCH FERNÁNDEZ, Javier, SÁNCHEZ LÓPEZ, José María
Format Patent
LanguageEnglish
French
German
Published 10.04.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to compound of general formula (I):wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in cancer such as Glioblastoma. The compounds have shown to be useful in therapy as modulators of TAP73 and stemness- and invasiveness-related genes. The compounds may be isolated from the fermentation broth of a fungal strain of Chaetomium sp., or are derivatives thereof. The strain of Chaetomium sp. HT-GU-SUES-904 with accession number CECT 20840 is also claimed.
Bibliography:Application Number: EP20220382943