BIODEGRADABLE TISSUE SCAFFOLD WITH SECONDARY MATRIX TO HOST WEAKLY ADHERENT CELLS

A scaffold containing two layers is provided for attaching retinal pigment epithelial (RPE) cells, photoreceptor progenitor (PRP) cells, or both. The scaffold includes a first layer containing poly(lactic-co-glycolic acid) (PLGA), and a second layer containing polycaprolactone (PCL) loops. Scaffolds...

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Main Authors MAMINISHKIS, Arvydas, NGUYEN, Eric, ORTOLAN, Davide, SHARMA, Ruchi, BHARTI, Kapil
Format Patent
LanguageEnglish
French
German
Published 10.04.2024
Subjects
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
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Abstract A scaffold containing two layers is provided for attaching retinal pigment epithelial (RPE) cells, photoreceptor progenitor (PRP) cells, or both. The scaffold includes a first layer containing poly(lactic-co-glycolic acid) (PLGA), and a second layer containing polycaprolactone (PCL) loops. Scaffolds containing mature RPE cells and PRP cells can be implanted into the eye of a subject to treat a retinal degenerative disease, retinal dysfunction, retinal degradation, retinal damage, or loss of retinal pigment epithelium.
AbstractList A scaffold containing two layers is provided for attaching retinal pigment epithelial (RPE) cells, photoreceptor progenitor (PRP) cells, or both. The scaffold includes a first layer containing poly(lactic-co-glycolic acid) (PLGA), and a second layer containing polycaprolactone (PCL) loops. Scaffolds containing mature RPE cells and PRP cells can be implanted into the eye of a subject to treat a retinal degenerative disease, retinal dysfunction, retinal degradation, retinal damage, or loss of retinal pigment epithelium.
Author SHARMA, Ruchi
BHARTI, Kapil
ORTOLAN, Davide
NGUYEN, Eric
MAMINISHKIS, Arvydas
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DocumentTitleAlternate ÉCHAFAUDAGE DE TISSU BIODÉGRADABLE AYANT UNE MATRICE SECONDAIRE POUR HÉBERGER DES CELLULES FAIBLEMENT ADHÉRENTES
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Snippet A scaffold containing two layers is provided for attaching retinal pigment epithelial (RPE) cells, photoreceptor progenitor (PRP) cells, or both. The scaffold...
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SubjectTerms CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
Title BIODEGRADABLE TISSUE SCAFFOLD WITH SECONDARY MATRIX TO HOST WEAKLY ADHERENT CELLS
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