SOLID DOSAGE FORMS AND DOSING REGIMENS COMPRISING (2R,3S,4S,5R)-4-[[3-(3,4-DIFLUORO-2-METHOXY-PHENYL)-4,5-DIMETHYL-5-(TRIFLUOROMETHYL) TETRAHYDROFURAN-2-CARBONYL]AMINO]PYRIDINE-2-CARBOXAMIDE

Provided is a solid dispersion of (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide (Compound 1), defined as described herein, or a pharmaceutically acceptable salt thereof and a tablet containing the solid di...

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Main Authors CORRELL, Darin J, CIRINCIONE, Brenda, STAROPOLI, John F, KARKARE, Radhika, BENITO GALLO, Paloma, HAY, Tanya Louise, MCCARTY, Katie L, DELFF, Philip Kaj Harder, METZLER, Catherine P, JONES, James B, MILLER, Jonathan M, DINEHART, Kirk Raymond, ROOPWANI, Rahul, PETERSON, Mark C, CHU, Cathy, JIANG, Licong
Format Patent
LanguageEnglish
French
German
Published 10.04.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Provided is a solid dispersion of (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide (Compound 1), defined as described herein, or a pharmaceutically acceptable salt thereof and a tablet containing the solid dispersion for treating pain. Also disclosed herein is Compound 1 or a pharmaceutically acceptable salt thereof for use in a method of treating pain.
AbstractList Provided is a solid dispersion of (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide (Compound 1), defined as described herein, or a pharmaceutically acceptable salt thereof and a tablet containing the solid dispersion for treating pain. Also disclosed herein is Compound 1 or a pharmaceutically acceptable salt thereof for use in a method of treating pain.
Author ROOPWANI, Rahul
MCCARTY, Katie L
DELFF, Philip Kaj Harder
CHU, Cathy
JIANG, Licong
PETERSON, Mark C
METZLER, Catherine P
STAROPOLI, John F
DINEHART, Kirk Raymond
JONES, James B
KARKARE, Radhika
BENITO GALLO, Paloma
HAY, Tanya Louise
CIRINCIONE, Brenda
MILLER, Jonathan M
CORRELL, Darin J
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– fullname: STAROPOLI, John F
– fullname: KARKARE, Radhika
– fullname: BENITO GALLO, Paloma
– fullname: HAY, Tanya Louise
– fullname: MCCARTY, Katie L
– fullname: DELFF, Philip Kaj Harder
– fullname: METZLER, Catherine P
– fullname: JONES, James B
– fullname: MILLER, Jonathan M
– fullname: DINEHART, Kirk Raymond
– fullname: ROOPWANI, Rahul
– fullname: PETERSON, Mark C
– fullname: CHU, Cathy
– fullname: JIANG, Licong
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DocumentTitleAlternate FORMES GALÉNIQUES SOLIDES ET SCHÉMAS POSOLOGIQUES COMPRENANT DU (2R,3S,4S,5R)-4-[[3-(3,4-DIFLUORO-2-MÉTHOXY-PHÉNYL)-4,5-DIMÉTHYL-5-(TRIFLUOROMÉTHYL)TÉTRAHYDROFURAN-2-CARBONYL]AMINO]PYRIDINE-2-CARBOXAMIDE
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Snippet Provided is a solid dispersion of (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl)...
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SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title SOLID DOSAGE FORMS AND DOSING REGIMENS COMPRISING (2R,3S,4S,5R)-4-[[3-(3,4-DIFLUORO-2-METHOXY-PHENYL)-4,5-DIMETHYL-5-(TRIFLUOROMETHYL) TETRAHYDROFURAN-2-CARBONYL]AMINO]PYRIDINE-2-CARBOXAMIDE
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