BIFUNCTIONAL DEGRADERS OF GALACTOSE-DEFICIENT IMMUNOGLOBULINS

An agent including a glycan-specific IgG antibody moiety, a cellular receptor binding moiety which binds to hepatocytes or other degrading cells through asialoglycoprotein (ASGPR) receptors of hepatocytes or other cell receptors which are on the surface degrading cells in a patient or subject, and o...

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Main Authors SPIEGEL, David, CALDWELL, Reese M, DUBOWCHIK, Gene M
Format Patent
LanguageEnglish
French
German
Published 17.01.2024
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Abstract An agent including a glycan-specific IgG antibody moiety, a cellular receptor binding moiety which binds to hepatocytes or other degrading cells through asialoglycoprotein (ASGPR) receptors of hepatocytes or other cell receptors which are on the surface degrading cells in a patient or subject, and optionally, a linker moiety connecting the glycan-specific IgG antibody moiety and the cellular receptor binding moiety.
AbstractList An agent including a glycan-specific IgG antibody moiety, a cellular receptor binding moiety which binds to hepatocytes or other degrading cells through asialoglycoprotein (ASGPR) receptors of hepatocytes or other cell receptors which are on the surface degrading cells in a patient or subject, and optionally, a linker moiety connecting the glycan-specific IgG antibody moiety and the cellular receptor binding moiety.
Author SPIEGEL, David
CALDWELL, Reese M
DUBOWCHIK, Gene M
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DocumentTitleAlternate BIFUNKTIONELLE DEGRADER VON IMMUNGLOBULINEN MIT DEFIZIENTER GALACTOSE
AGENTS DE DÉGRADATION BIFONCTIONNELS D'IMMUNOGLOBULINES DÉFICIENTES EN GALACTOSE
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RelatedCompanies Biohaven Therapeutics Ltd
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Snippet An agent including a glycan-specific IgG antibody moiety, a cellular receptor binding moiety which binds to hepatocytes or other degrading cells through...
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SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title BIFUNCTIONAL DEGRADERS OF GALACTOSE-DEFICIENT IMMUNOGLOBULINS
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