ADENOSINE DERIVATIVE HAVING ANTAGONISTIC ACTION ON A2A AND A3 ADENOSINE RECEPTORS AND METHOD FOR PREPARING SAME

• Main Authors: LEE, Hyuk Woo, KIM, Ji Won, KIM, Seo Hyun, CHOI, Jong Ryoul, JANG, Hyu Jeong, BYUN, Joon Seok, AHN, Sang Yeop, KANG, Ji Yoon, JI, Seung Hee, SON, Seo Hyun
• Format: Patent
• Language: English; French; German
• Published: 09.10.2024
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The present invention relates to: an adenosine derivative capable of acting as an antagonist on A2A and A3 adenosine receptors through the introduction of substituents into the 2nd and 8th carbons and 6th and/or 9th amine(s); a pharmaceutical composition including the same; and a method for preparing the same. The adenosine derivative regulates the activity of an A2A or A3 adenosine receptor, and thus can effectively prevent or treat brain diseases, cardiovascular diseases, sleep disorders, inflammation, immune system diseases and the like in which the receptors are involved.