PROCESS FOR THE PREPARATION OF ILOPROST

The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(5)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formul...

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Bibliographic Details
Main Authors SZABÓ, Tibor, KARDOS, Zsuzsanna, ROZSUMBERSZKI, Imre, VÁRADI, Csaba, BÁN, Tamás, HORTOBÁGYI, Irén
Format Patent
LanguageEnglish
French
German
Published 27.12.2023
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(5)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.
Bibliography:Application Number: EP20230207991