RITUXIMAB-RESISTANT CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD 19 antigen binding domain that specifically binds to CD 19 and is resistant to rituximab binding; and immune cells comprising these CD19-specific CARs, e.g., CAR-T cells. Also provided are methods of makin...

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Main Authors PERTEL, Thomas Charles, SASU, Barbra Johnson, LEONARD, Mark W
Format Patent
LanguageEnglish
French
German
Published 27.12.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD 19 antigen binding domain that specifically binds to CD 19 and is resistant to rituximab binding; and immune cells comprising these CD19-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using these CD 19-specific CARs, and immune cells comprising these CD19-specific CARs.
AbstractList Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD 19 antigen binding domain that specifically binds to CD 19 and is resistant to rituximab binding; and immune cells comprising these CD19-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using these CD 19-specific CARs, and immune cells comprising these CD19-specific CARs.
Author LEONARD, Mark W
SASU, Barbra Johnson
PERTEL, Thomas Charles
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DocumentTitleAlternate RÉCEPTEURS D'ANTIGÈNES CHIMÉRIQUES RÉSISTANT AU RITUXIMAB ET LEURS UTILISATIONS
RITUXIMAB-RESISTENTE CHIMÄRE ANTIGENREZEPTOREN UND DEREN VERWENDUNG
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RelatedCompanies Allogene Therapeutics, Inc
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Snippet Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD 19 antigen binding domain that specifically binds to CD 19 and...
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SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title RITUXIMAB-RESISTANT CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
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