STABILIZATION OF IMMUNOGLOBULINS THROUGH AQUEOUS FORMULATION WITH HISTIDINE AT WEAK ACIDIC TO NEUTRAL PH
The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to ne...
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| Main Authors | , , , , |
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| Format | Patent |
| Language | English French German |
| Published |
13.12.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration. |
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| AbstractList | The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration. |
| Author | SCHWARZ, Hans-Peter TESCHNER, Wolfgang KÖLBL, Bernhard GNAUER, Lucia BUTTERWECK, Harald Arno |
| Author_xml | – fullname: GNAUER, Lucia – fullname: TESCHNER, Wolfgang – fullname: KÖLBL, Bernhard – fullname: SCHWARZ, Hans-Peter – fullname: BUTTERWECK, Harald Arno |
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| DocumentTitleAlternate | STABILISATION DES IMMUNOGLOBULINES PAR UNE FORMULATION AQUEUSE ADDITIONNÉE D'HISTIDINE À UN PH FAIBLEMENT ACIDE À NEUTRE STABILISIERUNG VON IMMUNGLOBULINEN ANHAND EINER WÄSSRIGEN FORMULIERUNG MIT HISTIDIN BEI SCHWACH SAUREN BIS NEUTRALEM PH-WERT |
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| RelatedCompanies | Takeda Pharmaceutical Company Limited |
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| Snippet | The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH.... |
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| Title | STABILIZATION OF IMMUNOGLOBULINS THROUGH AQUEOUS FORMULATION WITH HISTIDINE AT WEAK ACIDIC TO NEUTRAL PH |
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