SPLICE SWITCHING OLIGONUCLEOTIDES TARGETING PSEUDOEXONS
The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5'...
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Main Authors | , , , , |
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Format | Patent |
Language | English French German |
Published |
06.12.2023
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Abstract | The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof. |
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AbstractList | The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof. |
Author | HOLM, Lise, Lolle PETERSEN, Ulrika Simone Spangsberg BRUUN, Gitte, Hoffmann ANDRESEN, Brage, Storstein DOKTOR, Thomas, Koed |
Author_xml | – fullname: PETERSEN, Ulrika Simone Spangsberg – fullname: HOLM, Lise, Lolle – fullname: ANDRESEN, Brage, Storstein – fullname: BRUUN, Gitte, Hoffmann – fullname: DOKTOR, Thomas, Koed |
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DocumentTitleAlternate | OLIGONUCLÉOTIDES À COMMUTATION D'ÉPISSAGE CIBLANT DES PSEUDOEXONS SPLEISSSCHALTENDE OLIGONUKLEOTIDE MIT PSEUDOEXONEN ALS ZIEL |
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RelatedCompanies | Syddansk Universitet |
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Snippet | The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by... |
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SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
Title | SPLICE SWITCHING OLIGONUCLEOTIDES TARGETING PSEUDOEXONS |
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