EXTENDED LOCAL RELEASE OF ANTIBODIES
The present disclosure provides compositions and methods for extended release of certain types of antibodies in vivo. It was discovered that such antibodies are able to initiate reversible gelation of hyaluronic acid (HA) by creating a depot that dissociates over time to release the antibody without...
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| Main Authors | , |
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| Format | Patent |
| Language | English French German |
| Published |
08.11.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present disclosure provides compositions and methods for extended release of certain types of antibodies in vivo. It was discovered that such antibodies are able to initiate reversible gelation of hyaluronic acid (HA) by creating a depot that dissociates over time to release the antibody without any impact on its physical and chemical properties as well as its biological activity. As certain tissues and organs, such as eyes, joints and skins, contain HA, local injection of the antibodies to these tissues or organs will result in embedding of the antibody in gel formed from the HA, which becomes a repository of slow-released antibodies. In addition, slow-released formulations can be prepared with antibodies mixed with HA, optionally with other polymers. |
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| AbstractList | The present disclosure provides compositions and methods for extended release of certain types of antibodies in vivo. It was discovered that such antibodies are able to initiate reversible gelation of hyaluronic acid (HA) by creating a depot that dissociates over time to release the antibody without any impact on its physical and chemical properties as well as its biological activity. As certain tissues and organs, such as eyes, joints and skins, contain HA, local injection of the antibodies to these tissues or organs will result in embedding of the antibody in gel formed from the HA, which becomes a repository of slow-released antibodies. In addition, slow-released formulations can be prepared with antibodies mixed with HA, optionally with other polymers. |
| Author | HSU, Chung-Chiang ALANI, Laman |
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| DocumentTitleAlternate | VERLÄNGERTE LOKALE FREISETZUNG VON ANTIKÖRPERN LIBÉRATION LOCALE ÉTENDUE D'ANTICORPS |
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| Notes | Application Number: EP20210916306 |
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| Snippet | The present disclosure provides compositions and methods for extended release of certain types of antibodies in vivo. It was discovered that such antibodies... |
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| Title | EXTENDED LOCAL RELEASE OF ANTIBODIES |
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