HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The present invention relates to novel 1,4-substituted piperidine compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of di...

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Main Authors PEVARELLO, Paolo, VITALONE, Rocco, TORINO, Domenica, ARTAMONOV, Oleksii, YOUSIF, Ali Munaim, PISCITELLI, Francesco, CUSANO, Valentina, SODANO, Mariangela
Format Patent
LanguageEnglish
French
German
Published 25.10.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel 1,4-substituted piperidine compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans
Bibliography:Application Number: EP20210836564