PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

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Main Authors LIN, Jian, CARAVELLA, Justin Andrew, DIEBOLD, R. Bruce, ERICSSON, Anna, LU, Wei, WANG, Zhongguo, GUSTAFSON, Gary, ASHWELL, Susan, LANCIA, David R. Jr, CAMPBELL, Ann-Marie
Format Patent
LanguageEnglish
French
German
Published 10.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
AbstractList The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
Author ASHWELL, Susan
CARAVELLA, Justin Andrew
GUSTAFSON, Gary
ERICSSON, Anna
WANG, Zhongguo
LIN, Jian
LANCIA, David R. Jr
CAMPBELL, Ann-Marie
DIEBOLD, R. Bruce
LU, Wei
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– fullname: CARAVELLA, Justin Andrew
– fullname: DIEBOLD, R. Bruce
– fullname: ERICSSON, Anna
– fullname: LU, Wei
– fullname: WANG, Zhongguo
– fullname: GUSTAFSON, Gary
– fullname: ASHWELL, Susan
– fullname: LANCIA, David R. Jr
– fullname: CAMPBELL, Ann-Marie
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DocumentTitleAlternate DÉRIVÉS DE PYRIDIN-2-(1H)-ONE-QUINOLINONE EN TANT QU'INHIBITEURS D'ISOCITRATE DÉSHYDROGÉNASE
PYRIDIN-2(1H)-ON-CHINOLIN-DERIVATE ALS INHIBITOREN DER MUTANTEN ISOCITRATDEHYDROGENASE
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Snippet The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
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